Research
My research interests include performing clinical studies in food allergy. Previous work has investigated the clinical features of severe food allergy and defined the usefulness of allergy tests in this context. Recent work includes clinical trials of oral immunotherapy for severe food allergy, and a clinical study of population thresholds in peanut allergy. With the help of Dr Sabita Islam we investigate the underlying immune mechanisms of oral immunotherapy, including work with cell culure and FACS anaplysis of basophils, allergen-specific T lymphocytes and regulatory cells.
Publications
Katherine Anagnostou , Sabita Islam, Yvonne King , Loraine Foley, Laura Pasea, Simon Bond , Chris Palmer , John Deighton , Pamela Ewan, Andrew Clark Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial The Lancet, Early Online Publication, 30 January 2014
Clark, Andrew, Mangat, Jay, King Yvonne, Islam, Sabita, Katherine Anagnostou, Loraine Foley, John Deighton, Ewan, Pamela. Thermographic imaging during nasal peanut challenge may be useful in the diagnosis of peanut allergy. Allergy 2012;67:574-6
Clark A, Islam S, King Y, Deighton J, Szun Sun Tay, Anagnostou K, Ewan P. A longitudinal study of resolution of allergy to well-cooked and uncooked egg. Clin Exp Allergy 2011; 41: 706-12.
Anagnostou K, Clark A, King Y, Islam S, Deighton J, Ewan P. Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome. Clin Exp Allergy 2011; 41: 1273-81
A. T. Clark, S. Islam, Y. King, J. Deighton, K. Anagnostou, P. W. Ewan. Successful oral tolerance induction in severe peanut allergy. Allergy 2009;64:1218-20.
Clark AT, Ewan PW. Good prognosis, clinical features and circumstances of peanut and tree nut reactions in children treated by a specialist allergy centre. J Allergy Clin Immunol 2008;122:286.
Tay SS, Clark AT, King Y, Deighton J, Ewan PW. T cell proliferation and cytokine responses to ovalbumin and ovomucoid detected in children with and without egg allergy. Clin Exp Allergy 2007;37:1519-27
