Research
The tumor stroma consists of the non-malignant cells of the tumor such as cancer-associated fibroblasts (CAFs) and immune cells. A role in tumor progression has been attributed to most of the components of the stroma. Particularly, it has been shown that CAFs are involved in tumor progression by promoting angiogenesis, invasion, and metastasis. The immune-regulating role of CAFs in primary tumours has been well documented, notably by the work of our lab, but their role in disrupting immune destruction of disseminated tumour cells and metastasis remains unclear. My work is focusing on the interactions between tumour cells, CAFs and immune cells in the first steps following colonisation of a target organ. I am especially trying to decipher the role of CAFs in the breaking-out of immune-mediated dormancy of disseminated tumour cells.
Publications
Pommier A., Lucas B. and Prévost-Blondel A. Crucial role of inflammatory monocytes in anti-tumor immunity Oncoimmunology. 2013 Nov 1;2(11):e26384.
Pommier A., Audemard A., Durand A., Lengagne R., Delpoux A., Martin B., Douguet L., Le Campion A., Kato M., Avril MF., Auffray C., Lucas B.* and Prévost-Blondel A.*. Inflammatory monocytes are potent anti-tumor effectors controlled by regulatory CD4 T cells. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13085-90. *Equal Contribution
Martin B., Auffray C., Delpoux A., Pommier A., Durand A., Charvet C., Yakonowsky P., de Boysson H., Bonilla N., Audemard A., Sparwasser T., Salomon B., Malissen B. and Lucas B. Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells. Nat Commun. 2013 Jul 31;4:2209.
Le Campion A.*, Pommier A.*, Delpoux A., Stouvenel L., Auffray C., Martin B.*, Lucas B.* IL-2 and IL-7 determine the homeostatic balance between the regulatory and conventional CD4+ T-cell compartments during peripheral T-cell reconstitution. J Immunol. 2012 Oct 1;189(7):3339-46. *Equal Contribution
Delpoux A., Poitrasson-Rivière M., Le Campion A., Pommier A., Yakonowsky P., Jacques S., Letourneur F., Randriamampita C., Lucas B. and Auffray C. Foxp3-independent loss of regulatory CD4+ T-cell suppressive capacities induced by self-deprivation. Eur J Immunol. 2012 May;42(5):1237-49.
Lengagne R.*, Pommier A.*, Caron, J., Garcette M., Kato M., Avril MF., Abastado JP., Bercovici N., Lucas B., Prévost-Blondel A. T cells contribute to spontaneous melanoma progression by favoring pro-tumoral properties of intra-tumoral myeloid cells. PLoS One. 2011;6(5):e20235. *Equal Contribution
