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Christian Hüber

Research Interests

Supervisor: Francesco Colucci

NK cells are classically regarded as being members of the innate immune system. Recent evidence suggests, however, that also NK cells are able to "remember" previous activation and to mount more efficient immune responses upon re-encountering virus-infected cells.

In my project I want to prove the evidence for "memory" NK cells, characterise them and determine their relevance in virus infection and cancer.

Keywords

NK ; signal transduction ; innate immunity ; cell culture ; animal models ; natural killer receptors ; FACS ; signalling ; natural killer cells ; memory cells

Topics

  • vaccines
  • cancer

Key Publications

Binder M, Sulaimanov N, Clausznitzer D, Schulze M, Hüber CM, Lenz SM, Schlöder JP, Trippler M, Bartenschlager R, Lohmann V, Kaderali L. Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle. PLoS Pathog. 2013;9(8):e1003561.

Binder M, Eberle F, Seitz S, Mücke N, Hüber CM, Kiani N, Kaderali L, Lohmann V, Dalpke A, Bartenschlager R, Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I), J Biol Chem. 2011 Aug 5;286(31):27278–87.

Mora R, Dokic I, Kees T, Hüber CM, Keitel D, Geibig R, Brügge B, Zentgraf H, Brady NR, Régnier-Vigouroux A  Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma, Glia. 2010 Aug 15;58(11):1364–83