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Dr Craig Taylor

Director of Histocompatibility and Immunogenetics

Consultant Clinical Scientist


Research Interests

Our laboratory provides Histocompatibility and Immunogenetics (Tissue Typing) services for one of the largest clinical transplant repertoires in the UK (kidney, pancreas, heart, lung, liver, intestinal and multi-visceral organ transplantation, and haematopoietic stem cell transplantation). Our research interests focus on the role of HLA matching and HLA-specific allosensitisation to improve access to and clinical outcome of solid organ transplantation.

Keywords

alloantibodies ; stem cell transplantation ; organ transplantation ; HLA-epitopes ; histocompatibility ; allosensitisation ; polymorphisms ; immunogenetics ; HLA

Key Publications

Kosmoliaptsis V, Gjorgjimajkoska O, Sharples LD, Chaudhry AN, Chatzizacharias N, Peacock S, Torpey N, Bolton EM, Taylor CJ, Bradley JA. Impact of donor mismatches at individual HLA-A, -B, -C, -DR and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation. Kidney International 2014: advanced publication, 9 April 2014; doi: 10.1038/ki.2014.106.

Taylor CJ, Peacock S, Chaudhry AN, Bradley JA, Bolton EM. Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types. Cell Stem Cell 2012: 11; 147-152.

Kosmoliaptsis V, Dafforn TR, Chaudhry AN, Halsall DJ, Bradley JA, Taylor CJ. High resolution three-dimensional modelling of HLA class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes. Human Immunology 2011. Hum Immunol. 2011; 72:1049-59.

Kosmoliaptsis V, Sharples LD, Chaudhry AN, Halsall DJ, Bradley JA, Taylor CJ. Predicting HLA class II alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms. Transplantation 2011; 91: 183-190.

Taylor CJ, Kosmoliaptsis, Sharples LD, Prezzi D, Morgan CH, Key T, Chaudhry AN, Amin I, Clatworthy MR, Butler AJ, Watson CJE, Bradley JA. Ten year experience of selective omission of the pre-transplant crossmatch test in deceased donor kidney transplantation. Transplantation 2010; 89:185-193.

Taylor CJ, Bolton EM, Pocock S, Sharples LD, Pedersen RA, Bradley JA. Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet 2005; 366: 2019-2025.