Francesco Colucci is accepting applications for PhD students.
Francesco Colucci is available for consultancy.
- Innate immunity:
Uterine NK cells
- Department of Obstetrics and Gynaecology :
- University Reader
Natural killer cells meet invasive cells: what consequences on cancer and reproduction?
Our lab studies the complex interactions between NK cell receptors and molecules expressed on invasive cells, including cancerous cells but also fetal placental cells that invade into the womb.
We are interested in:
cytotoxicity ; development ; NK ; natural killer receptors ; cell culture ; cell development ; pregnancy ; natural killer cells ; fluorescence microscopy ; lymphocytes, ; differentiation ; FACS ; lymphocyte activation
Moffett A, Colucci F. (2015). Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction.Immunol Rev. Sep;267(1):283-97.
Colucci F, Moffett A, and Trowsdale J (2014). Medawar and the immunological paradox of pregnancy: 60 years on. Eur J. Immunol. 44(7): 1883-1885
Xiong S, Sharkey AM, Kennedy PR, Gardner L, Farrell LE, Chazara O, Bauer J, Hiby SE, Colucci F, Moffett A.Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation. J Clin Invest. 2013 Oct 1;123(10):4264-72.
Ormiston ML, Chang C, Long LL, Soon E, Jones D, Machado R, Treacy C, Toshner MR, Campbell K, Riding A, Southwood M, Pepke-Zaba J, Exley A, Trembath RC, Colucci F, Wills M, Trowsdale J, Morrell NW.Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension. Circulation. 2012 Aug 28;126(9):1099-109
Complete list of publications is found at :