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Florian Gessler

Research Interests

Supervisor: Dr. Stefano Pluchino

I am interested in the interaction between extracellular RNA and the immune system. My research particularly focuses on the analysis of extracellular vesicles and exosomes as a carrier for micro RNA.

Keywords

microRNA ; NPCs ; extracellular vesicles ; immune system ; exosome

Key Publications

F. Gessler, V. Voss, S. Duetzmann, V. Seifert, R. Gerlach, D. Koegel, Inhibition of TissueFactor signalling limits proliferation, migration and invasion of low and high grade glioma cells. Neuroscience 165 (2010) 1312-1322 

S. Duetzmann, F. Gessler, P. Harter, V. Seifert, R. Gerlach, D. Koegel, Recent evidence for a pro-migratory and pro-invasive function of the procoagulant Tissue Factor in malignant gliomas. Cell Adh Migr 2010 Oct 15; 4(4)

F. Gessler, V. Seifert, R. Gerlach, D. Koegel, TFPI-2 signalling plays a fundamental role in proliferation, cell death and invasion in low and high grade glioma cells. Neurosci Lett. 2011 Jun 15; 497(1)

Harter PN, S. Duetzmann, U. Drott, E. Hattingen, D. Capper, F. Gessler, C. Senft, V. Seifert, KH. Plate, D. Koegel, M. Mittelbronn, Anti-tissue factor (TF9-10H10) treatment reduces tumor cell invasiveness in a novel migratory glioma model. Neuropathology. 2013 Feb 5;

J. Mani, S. Vallo, S. Rakel, P. Antonietti, F. Gessler, R. Blaheta, G. Bartsch, M. Michaelis, J. Cinatl, A. Haferkamp and D Koegel, Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer. 2015 Apr 7; 15(1):224

P. Antonietti, F. Gessler, H. Duessmann, C. Reimertz, M. Mittelbronn, J. H. Prehn, D. Kögel, AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localisation of Bcl-xL and Bcl-2 in MCF7 cells.Biochim Biophys Acta. 2015 Dec 22