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Dr Janet Deane

Dr Janet Deane

Royal Society University Research Fellow

Deputy Director Wellcome Trust 4-year PhD Programme in Infection and Immunity


Research Interests

I use molecular modeling and protein crystallography to answer questions about protein:protein interactions such as host-pathogen interactions and MHC: chaperone interactions. 

Keywords

molecular modeling ; molecular biology ; MHC class I ; modelling ; x-ray crystallography

Key Publications

Hermann C, Strittmatter LM, Deane JE, Boyle LH. The Binding of TAPBPR and Tapasin to MHC Class I Is Mutually Exclusive. J Immunol. 2013 Dec 1;191(11):5743-50.

Graham SC, Wartosch L, Gray SR, Scourfield EJ, Deane JE, Luzio JP, Owen DJ.Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13345-50. 

Deane JE, Graham SC, Kim NN, Stein PE, McNair R, Cachón-González MB, Cox TM, Read RJ. Insights into Krabbe disease from structures of galactocerebrosidase. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15169-73.

Deane JE, Graham SC, Mitchell EP, Flot D, Johnson S, Lea SM.Crystal structure of Spa40, the specificity switch for the Shigella flexneri type III secretion system. Mol Microbiol. 2008 Jul;69(1):267-76. 

Deane JE, Roversi P, King C, Johnson S, Lea SM. Structures of the Shigella flexneri type 3 secretion system protein MxiC reveal conformational variability amongst homologues. J Mol Biol. 2008 Apr 4;377(4):985-92.

Deane JE, Roversi P, Cordes FS, Johnson S, Kenjale R, Daniell S, Booy F, Picking WD, Picking WL, Blocker AJ, Lea SM. Molecular model of a type III secretion system needle: Implications for host-cell sensing. Proc Natl Acad Sci U S A. 15;103(33):12529-33.