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Dr Jyoti Choudhary

Research Interests

We are interested in solving questions about the biology underlying health and disease by studying molecular processes and pathways. To do this we use a range of techniques including mass spectrometry, biochemistry, molecular biology and informatics, to study protein function, proteome composition and organisation.

The Proteomic mass spectrometry team complements the research programmes of the Sanger Institute to further understanding of the relationship between the genome and the proteome (expressed protein complement). Through our research and collaborations we explore protein-protein interactions, cell signalling and protein expression in a range of human, pathogen and model organisms.

Our research portfolio encompasses all levels of proteome complexity: from whole organism characterisation to subcellular organelles, from protein complexes to post-translation modifications.

Keywords

mass spectrometry

Key Publications

Jones ML, Collins MO, Goulding D, Choudhary JS, Rayner JC. Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis. Cell Host Microbe. 2012 Aug 16;12(2):246-58.

Sebastian S, Brochet M, Collins MO, Schwach F, Jones ML, Goulding D, Rayner JC, Choudhary JS, Billker O. A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs. Cell Host Microbe. 2012 Jul 19;12(1):9-19.

Pardo M, Choudhary JS. Assignment of protein interactions from affinity purification/mass spectrometry data. J Proteome Res. 2012 Mar 2;11(3):1462-74.

Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell. 2010 Apr 2;6(4):382-95.

Brosch M, Choudhary J. Scoring and validation of tandem MS peptide identification methods. Methods Mol Biol. 2010;604:43-53.

Collins MO, Choudhary JS. Mapping multiprotein complexes by affinity purification and mass spectrometry. Curr Opin Biotechnol. 2008 Aug;19(4):324-30.