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Jiro Sakai

Research Interests

Supervisor Professor Clare Bryant

I am interested in the interaction between host cells and pathogens to find a new therapeutic target. I currently investigate Toll-like receptor 4 signaling to NF-κB activation leading to inflammatory gene expression in macrophages in response to Salmonella enterica serovar Typhimurium. My main work is the confocal microscopy of dynamic NF-κB nuclear translocation in a live cell.

Key Publications

Sakai J, Li J, Subramanian KK, Mondal S, Bajrami B, Hattori H, Jia Y, Dickinson BC, Zhong J, Ye K, Chang CJ, Ho YS, Zhou J, Luo HR. Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity 2012 Dec 14;37(6): 1037-49

Mondal S, Subramanian KK, Sakai J, Bajrami B, Luo HR. Phophoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion. Mol Biol Cell 2012 Apr;23(7): 1219-30

Prasad A, Jia Y, Chakraborty A, Li Y, Jain SK, Zhong J, Roy SG, Loison F, Mondal S, Sakai J, Blanchard C, Snyder SH, Luo HR. Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-triphosphate signaling. Nat Immunol 2011 Jun19;12(8): 752-60

Hattori H, Subramanian KK, Sakai J, Luo HR. Reactive oxygen species as signaling molecules in neutrophil chemotaxis. Commun Integr Biol 2010 May;3(3): 278-81

Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HR. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci USA 2010 Feb 23;107(8): 3546-51

Sakai J, Karino T, Niwa K. Flow-dependent accumulation of LDL in co-cultures of endothelial and smooth muscle cells in the presence of filtration flow through the cell layer. Clin Hemorheol Microcirc 2008;38(4): 245-56