Next Generation Fellow - Centre for Trophoblast Research
Jens Kieckbusch is accepting applications for PhD students.
The maternal immune system mediates key adaptations necessary for successful pregnancy, but do pregnancy complications affect immune system development in the offspring? Most components of our immune system develop during the intrauterine period. Jens’ research focusses on how common pregnancy complications, especially those linked to defective placentation, impinge on fetal immune development.
A strong immune system is key for the survival of neonates and may also lay the foundation for healthy adulthood. By better understanding the mechanisms that link intrauterine development and immunity, we aim to define special requirements new-borns from complicated pregnancies have.
Jens’ approach focusses on flow cytometry, immunohistochemistry, stereology and confocal microscopy.
cytokine/interleukin/chemokine receptors ; differentiation ; natural killer cells ; cell culture ; confocal microscopy ; pregnancy ; cytokines ; trophoblast ; adhesion molecules ; decidual artery remodelling ; allorecognition ; immunohistochemistry ; activation ; traffic ; natural killer receptors ; cytotoxicity ; circulation ; microscopy ; cell development ; fluorescence microscopy ; FACS ; uterine natural killer cells ; migration
Jens Kieckbusch, Elisa Balmas, Delia A Hawkes, Francesco Colucci. Disrupted PI3K p110δ Signaling Dysregulates Maternal Immune Cells and Increases Fetal Mortality In Mice. Cell Reports. 2015.
Kieckbusch J, Gaynor LM, Colucci F. Assessment of maternal vascular remodeling during pregnancy in the mouse uterus. JoVE (Journal of Visualized Experiments), e53534-e53534. 2015
Jean-Marc Doisne, Elisa Balmas, Selma Boulenouar, Louise M Gaynor, Jens Kieckbusch et al. Composition, Development, and Function of Uterine Innate Lymphoid Cells. The Journal of Immunology 195 (8), 3937-3945
Colucci F and Kieckbusch J. Maternal uterine natural killer cells nurture fetal growth: in medio stat virtus. Trends in Molecular Medicine. 2015 21 (2). 60-67.
Kieckbusch J, Gaynor LM, Moffett A, Colucci F. MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling. Nature Communications. 2014 5:3359. DOI 10.1038/ncomms4359
Colucci F, Boulenouar S, Kieckbusch J, Moffett A. How does variability of immune system genes affect placentation? Placenta. 2011 Aug;32(8):539-45.
Walters SB, Kieckbusch J, Nagalingam G, Swain A, Latham SL, Grau GE, Britton WJ, Combes V, Saunders BM. Microparticles from mycobacteria-infected macrophages promote inflammation and cellular migration. The Journal of Immunology. 2013 190 (2), 669-677.