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Dr Krzysztof Kolmus

Research Interests

My research focuses at developing a complete antagonist(s) of an innate immune receptor. I take advantage of various cell-based approaches to screen a large library of compounds in order to select the most potent and non-cytotoxic ligands. Using structural biology methods, I want to confirm direct interaction between these molecules and receptor. In parallel, direct interactors active in the low concentrations will be chemically modified to improve their antagonistic parameters.

Keywords

β2-adrenergic receptors ; TLR4 ; NF-κB ; cytokine and chemokine gene expression

Key Publications

β2-Adrenergic receptors in immunity and inflammation: stressing NF-κB.

Kolmus K, Tavernier J, Gerlo S.

Brain Behav Immun. 2015 Mar;45:297-310. doi: 10.1016/j.bbi.2014.10.007. Epub 2014 Oct 22. Review.

 

β-agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms.

Kolmus K, Van Troys M, Van Wesemael K, Ampe C, Haegeman G, Tavernier J, Gerlo S.

PLoS One. 2014 Mar 6;9(6):e90649. doi: 10.1371/journal.pone.0090649. eCollection 2014.