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Dr Pietro Mastroeni

Dr Pietro Mastroeni

Pietro Mastroeni is accepting applications for PhD students.

Pietro Mastroeni is available for consultancy.


Research Interests

My research is multidisciplinary and focuses on pathogenesis and immunity to bacterial infections and on vaccine development. My group has developed new biological and mathematical approaches to study the interaction of bacteria with individual cell in vivo and to analyse the interplay between bacterial virulence genes and host resistance genes/mechanisms.

I am actively involved in the study of the cross-talk between different cell populations in the initiation and expression of host immunity to bacteria. My research also investigates the role of innate cell receptors (e.g. TLRs) and acquired immune receptors (e.g. FcR) in infection control and vaccine function.

Other collaborative lines of research are exploring new areas within infection such as the interplay between microbes and autoimmune diseases and the possibility to use recombinant bacteria as anti-cancer agents.

Keywords

phagocytosis ; B cells ; microarrays ; microscopy ; confocal microscopy ; interleukin ; cytokines ; molecular biology ; B cell receptor (BCR) ; pathogenesis ; regulation ; inflammation ; monocytes ; proteomics ; immunity ; enzyme assays ; immunohistochemistry ; Fc receptors ; macrophages ; apoptosis ; activation ; immunoglobulins ; T cells ; human studies ; antibody responses ; animal models ; helper T cells ; cell culture ; fluorescence microscopy ; FACS

Topics

  • type I diabetes
  • vaccines
  • autoimmunity

Key Publications

Gog JR, Murcia A, Osterman N, Restif O, McKinley TJ, Sheppard M, Achouri S, Wei B, Mastroeni P, Wood JL, Maskell DJ, Cicuta P, Bryant CE. Dynamics of Salmonella infection of macrophages at the single cell level. J R Soc Interface. 2012 Oct 7;9(75):2696-707.

Wheeler DW, Thompson AJ, Corletto F, Reckless J, Loke JC, Lapaque N, Grant AJ, Mastroeni P, Grainger DJ, Padgett CL, O'Brien JA, Miller NG, Trowsdale J, Lummis SC, Menon DK, Beech JS. Anaesthetic impairment of immune function is mediated via GABA(A) receptors. PLoS One. 2011 Feb 24;6(2):e17152.

Newland SA, Phillips JM, Mastroeni P, Azuma M, Zaccone P, Cooke A.PD-L1 blockade overrides Salmonella typhimurium-mediated diabetes prevention in NOD mice: no role for Tregs. Eur J Immunol. 2011 Oct;41(10):2966-76.

Janis C, Grant AJ, McKinley TJ, Morgan FJ, John VF, Houghton J, Kingsley RA, Dougan G, Mastroeni P. In vivo regulation of the Vi antigen in Salmonella and induction of immune responses with an in vivo-inducible promoter. Infect Immun. 2011 Jun;79(6):2481-8.

Barr T, Brown S, Mastroeni P, Gray D. TLR and BCR signals to B cells differentially programme primary and memory Th1 responses to Salmonella enterica.. J, Immunol. 2010, 185: 2783–2789.

A dynamic view of the spread and intracellular distribution of Salmonella enterica. Pietro Mastroeni A, Grant O, Restif D, Maskell. Nature Rev. Microbiol. 2009; 7: 73–80.

Multifluorescence focal analysis of infected liver tissue showing an intracellular bacterium in a phagocyte.