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Jessica Mchugh

Research Interests

Supervisor: Dr Martin Turner

My research: The Tis11 family are a group of RNA binding proteins which negatively regulate gene expression by destabilizing target mRNA and inhibiting their translation. These proteins, named TTP (Zfp36), Tis11b (Zfp36l1) and Tis11b (Zfp36l2), are highly conserved and knockout studies within the Turner lab have demonstrated a context-dependent functional redundancy between these proteins. My PhD project is aimed at looking at the role of these proteins within naïve CD4 T cell activation.