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Matthew Elder

Research Interests

Supervisor: Professor Hill Gaston

My research interests are currently focused on immune regulation, specifically the role of innate immunity in inflammatory conditions. I am currently undertaking a PhD at the University of Cambridge within this field.

I graduated from the University of Leeds in 2006 with a BSc in Medical Sciences, and subsequently work at GlaxoSmithKline investigating novel therapies for steroid-resistant asthma. I then completed my Masters degree in Immunology at Imperial College London in 2010 where my work was focused on investigating effects of cytokines on memory CD8+ T cells.

I then joined King’s College London in October 2010 where I investigated the clinical potential of regulatory T cells; firstly in type 1 diabetes, and subsequently with regard to developing protocols for the safe and reproducible expansion of gut-tropic Tregs for use in Inflammatory Bowel Disease.

Keywords

western blot ; RT-PCR ; innate immunity ; regulatory T cells ; sterile tissue culture ; primary cell line generation ; FACS ; adaptive immunity ; ELISA's ; ELIspot ; memory cells

Topics

  • inflammatory bowel disease
  • type I diabetes
  • asthma
  • inflammatory arthritis

Key Publications

Byrne SM, Aucher A, Alyahya S, Elder M, Olson ST, Davis DM, Ashton-Rickardt PG.  Cathepsin B controls the persistence of memory CD8+ T lymphocytes. J Immunol. 2012 Aug 1;189(3):1133-43. doi: 10.4049/jimmunol.1003406. Epub 2012 Jun 27.