Research
Supervisor: Professor Arthur Kaser
I study the mechanisms arising genetic factors underlying intestinal inflanation. Unresolved endoplasmic reticulum (ER) stress can provoke intestinal inflammation. Hypomorphic variants of the ER stress transcription factor X-box binding protein 1 (XBP1) are associated with inflammatory bowel disease (IBD). Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such as X-box-binding protein 1 (XBP1), confer genetic risk for inflammatory bowel disease. The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic (HM) activity, causes Paneth cell dysfunction.
Publications
Niederreiter L, Adolph TE, Kaser A. Anti-IL-12/23 in Crohn's Disease: Bench and Bedside. Curr Drug Targets. 2013 Oct 13. [Epub ahead of print]
Adolph TE*, Tomczak MF*, Niederreiter L*, Ko HJ*, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013 Oct 2. doi: 10.1038/nature12599. * joint first author
Niederreiter L, Fritz TM, Adolph TE, Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S, Tomczak MF, Kaneider NC, Sarcevic E, Kempster SL, Raine T, Esser D, Rosenstiel P, Kohno K, Iwawaki T, Tilg H, Blumberg RS, Kaser A. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med. 2013 Sep 23;210(10):2041-56.
Adolph TE, Niederreiter L, Blumberg RS, Kaser A. Endoplasmic reticulum stress and inflammation. Dig Dis. 2012;30(4):341-6.
Kaser A, Niederreiter L, Blumberg RS. Genetically determined epithelial dysfunction and its consequences for microflora-host interactions. Cell Mol Life Sci. 2011 Nov;68(22):3643-9.
Niederreiter L, Kaser A. Endoplasmic reticulum stress and inflammatory bowel disease. Acta Gastroenterol Belg. 2011 Jun;74(2):330-3.
Fritz T, Niederreiter L, Adolph T, Blumberg RS, Kaser A. Crohn's disease: NOD2, autophagy and ER stress converge. Gut. 2011 Nov;60(11):1580-8.
Fritz T, Niederreiter L, Tilg H, Blumberg RS, Kaser A. Controversy over NOD2, inflammation, and defensins. Inflamm Bowel Dis. 2010 Nov;16(11):1996-8.
