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Dr Rebeccah Mathews

Research Interests

Research Assistant to Dr Menna Clatworthy

I did my PhD with Professor Michael McDermott at the Leeds Institute of Molecular Medicine on NOD-like receptors and inflammation.

Keywords

magnetic resonance ; innate immunity ; inflammation

Topics

  • rheumatoid arthritis
  • renal transplantation
  • renal disease

Key Publications

Clatworthy MR, Petrie Aronin CE, Matthews RJ, Morgan NY, Smith KG, Germain RN. Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes. Nature Medicine (2014) doi:10.1038/nm.3709

Clatworthy MR, Matthews RJ, Doehler B, Willcocks LC, Opelz G, Smith KG. Defunctioning Polymorphism in the Immunoglobulin G Inhibitory Receptor (FcγRIIB-T/T232) Does not Impact on Kidney Transplant or Recipient Survival. Transplantation. 2014 Aug 15;98(3):285-91.

Clatworthy MR, Kettunen MI, Hu DE, Mathews RJ, Witney TH, Kennedy BW, Bohndiek SE, Gallagher FA, Jarvis LB, Smith KG, Brindle KM. Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33)

Coulthard LR, Geiler J, Mathews RJ, Church LD, Dickie LJ, Cooper DL, Wong C, Savic S, Bryer D, Buch MH, Emery P, Morgan AW, McDermott MF. Differential effects of infliximab on absolute circulating blood leucocyte counts of innate immune cells in early and late rheumatoid arthritis patients. Clin Exp Immunol. 2012 Oct;170(1):36-46

Dickie LJ, Church LD, Coulthard LR, Mathews RJ, Emery P, McDermott MF.Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatology (Oxford). 2010 Aug;49(8):1466-71.

Mathews RJ, Sprakes MB, McDermott MF. NOD-like receptors and inflammation. Arthritis Res Ther. 2008;10(6):228.

Touitou I, Savic S, Mathews RJ, Grateau G, McDermott MF. Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases. Expert Rev Clin Immunol. 2008 Jul;4(4):425-8.

Churchman SM, Church LD, Savic S, Coulthard LR, Hayward B, Nedjai B, Turner MD, Mathews RJ, Baguley E, Hitman GA, Gooi HC, Wood PM, Emery P, McDermott MF. A novel TNFRSF1A splice mutation associated with increased nuclear factor kappaB (NF-kappaB) transcription factor activation in patients with tumour necrosis factor receptor associated periodic syndrome (TRAPS). Ann Rheum Dis. 2008 Nov;67(11):1589-95.