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Dr Roman Hovorka

Dr Roman Hovorka

Roman Hovorka is accepting applications for PhD students.


Research Interests

As a non-clinical researcher, my career has been dedicated to gaining insights into physiology through mathematical modelling and developing control algorithms, the step-by-step calculations that lie at the heart of the ‘artificial pancreas’ currently in development. I joined the University of Cambridge in 2004 to pursue his work on the ‘artificial pancreas’, a medical device that measures blood glucose levels on a minute-to-minute basis using a continuous glucose monitor, and transmits this information to a control algorithm, which instructs an insulin pump to release the required amount of insulin into the body. The work has substantive funding from Juvenile Diabetes Research Foundation, Diabetes UK, National Institute of Health, NIHR, and the European Commission. As a member of the JDRF’s Artificial Pancreas Consortium, I lead the development and testing of the ‘artificial pancreas’ in Type 1 diabetes. My current additional research interests include glucose control in the critically ill, the use of stable label tracers to probe glucose metabolism, and the development of virtual populations to supplement clinical testing of novel treatment modalities.

    Key Publications

    D. Elleri, J. M. Allen, K. Kumareswaran, L. Leelarathna, M. Nodale, K. Caldwell, P. Cheng, C. Kollman, A. Haidar, H. R. Murphy, M. E. Wilinska, C. L. Acerini, D. B. Dunger, and R. Hovorka. Closed-loop basal insulin delivery over 36 hours in adolescents with type 1 diabetes: Randomized clinical trial. Diabetes Care (in press), 2012.


    H. R. Murphy, D. Elleri, J. M. Allen, J. Harris, D. Simmons, G. Rayman, R. C. Temple, A. M. Umpleby, D. B. Dunger, A. Haidar, M. Nodale, M. E. Wilinska, and R. Hovorka. Pathophysiology of postprandial hyperglycaemia in women with type 1 diabetes during pregnancy. Diabetologia 55 (2):282-293, 2012.


    D. Elleri, J. M. Allen, M. Biagioni, K. Kumareswaran, L. Leelarathna, K. Caldwell, M. Nodale, M. E. Wilinska, C. L. Acerini, D. B. Dunger, and R. Hovorka. Evaluation of a portable ambulatory prototype for automated overnight closed-loop insulin delivery in young people with type 1 diabetes. Pediatr.Diabetes 13 (6):449-453, 2012.


    H. R. Murphy, D. Elleri, J. M. Allen, D. Simmons, M. Nodale, and R. Hovorka. Plasma C-peptide concentration in women with Type 1 diabetes during early and late pregnancy. Diabet.Med. 29 (10):e361-e364, 2012.


    A. Haidar, D. Elleri, J. M. Allen, J. Harris, K. Kumareswaran, M. Nodale, C. L. Acerini, M. E. Wilinska, N. Jackson, A. M. Umpleby, M. L. Evans, D. B. Dunger, and R. Hovorka. Validity of triple- and dual-tracer techniques to estimate glucose appearance. Am.J.Physiol Endocrinol.Metab 302 (12):E1493-E1501, 2012.


    H. Thabit and R. Hovorka. Closed-loop insulin delivery in type 1 diabetes. Endocrinol.Metab Clin.North Am. 41 (1):105-117, 2012.