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Dr Seth Thomas Scanlon

Departments

MRC Laboratory of Molecular Biology:
MRC Career Development Fellow

Research Interests

The interaction between innate and adaptive type 2 immunity; imaging immune cell trafficking and function; vaccine development; the regulation and resolution of immune responses.

Keywords

granulocytes ; helminths ; immune regulation ; innate lymphoid cells ; lung immunity ; vaccines ; chemotaxis ; imaging ; NKT cells ; skin immunity

Topics

  • allergy
  • asthma

Collaborators

Key Publications

Oliphant CJ, Hwang YY, Walker JA, Salimi M, Wong SH, Brewer JM, Englezakis A, Barlow JL, Hams E, Scanlon ST, Ogg GS, Fallon PG, McKenzie AN.MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion Immunity. 2014 Aug 21;41(2):283-95.

Salimi M, Barlow JL, Saunders SP, Xue L, Gutowska-Owsiak D, Wang X, Huang LC, Johnson D, Scanlon ST, McKenzie AN, Fallon PG, Ogg GS. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med. 2013 Dec 9.

Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A. BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
Nature. 2012 Nov 22;491(7425):618-21 

Scanlon ST, Thomas SY, Ferreira CM, Bai L, Krausz T, Savage PB, Bendelac A. Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation. J Exp Med. 2011 Sep 26;208(10):2113-24.

Thomas SY, Scanlon ST, Griewank KG, Constantinides MG, Savage AK, Barr KA, Meng F, Luster AD, Bendelac A. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.
J Exp Med. 2011 Jun 6;208(6):1179-88.