Research
I am interested in the biological mechanisms underlying intestinal inflammation. I am currently working in Professor Arthur Kaser’s group, researching how genes associated with inflammatory bowel disease influence the function of innate immune cells such as macrophages, and how dysregulation of these cells leads to chronic inflammation.
Publications
Smith A, Sewell G, Levine A, Chew T, Dunne J, O'Shea N, Smith P, Harrison P, Macdonald C, Bloom S, Segal A. Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients. Immunology. 2014 Jun 18. [Epub ahead of print]
O'Brien AJ, Fullerton JN, Massey KA, Auld G, Sewell G, James S, Newson J, Karra E, Winstanley A, Alazawi W, Garcia-Martinez R, Cordoba J, Nicolaou A, Gilroy DW. Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2. Nat Med. 2014 May;20(5):518-23.
Roden DL, Sewell GW, Lobley A, Levine AP, Smith AM, Segal AW. ZODET: Software for the Identification, Analysis and Visualisation of Outlier Genes in Microarray Expression Data. PLoS One 2014 Jan 8;9(1):e81123.
Sewell GW, Rahman FZ, Levine AP, Jostins L, Smith PJ, Walker AP, Bloom SL, Segal AW, Smith AM. Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: Relationship to phenotype and genome-wide association susceptibility loci. Inflamm Bowel Dis. 2012 Nov;18(11):2120-7.
Sewell GW, Hannun YA, Han X, Koster G, Bielawski J, Goss V, Smith PJ, Rahman FZ, Vega R, Bloom SL, Walker AP, Postle AD, Segal AW. Lipidomic profiling in Crohn's disease: Abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. Int J Biochem Cell Biol. 2012 Nov;44(11):1839-1846.
Smith AM, Rahman FZ, Hayee B, Graham SJ, Marks DJ, Sewell GW, Palmer CD, Wilde J, Foxwell BM, Gloger IS, Sweeting T, Marsh M, Walker AP, Bloom SL, Segal AW. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med. 2009 Aug 31;206(9):1883-97
