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Sam Hall

Research Interests

My work focuses on the interplay between infection and autoimmunity. In particular, I am investigating the potential of products derived from Schistosoma mansoni to skew or modulate immune activity in ways that might be relevant in the prevention or treatment of type 1 diabetes or other autoimmune diseases.

Keywords

co-stimulation ; co-stimulatory molecules ; anergy ; protein purification ; non-obese diabetic ; statistical analysis ; confocal microscopy ; differentiation ; antigen presentation ; regulatory T cells ; T cell receptor (TCR) ; cytokines ; helminths ; cross-sectional and cohort studies ; natural killer T cells (NKT cells) ; helper T cells ; adhesion molecules ; interleukin ; carbohydrate biology ; monocytes ; tolerance ; Toll-like receptors ; inflammation ; immunohistochemistry ; antigen processing ; macrophages ; cytotoxic T cells (CTL) ; activation ; T cells ; animal models ; gamma delta T cells ; suppression ; glycobiology ; pattern recognition receptors ; cell surface molecules ; inflammatory mediators ; microscopy ; cell development ; chemokines/monokines ; fluorescence microscopy ; FACS ; dendritic cells ; Toll receptors

Topics

  • rheumatoid arthritis
  • arthritis
  • type I diabetes
  • inflammatory bowel disease
  • multiple sclerosis
  • Graves' disease

Key Publications

Hall SW, Cooke A. Autoimmunity and inflammation: murine models and translational studies. Mamm Genome. 2011 Aug;22(7-8):377-89.