skip to primary navigationskip to content
 

Dr Sergey Nejentsev

Dr Sergey Nejentsev

Sergey Nejentsev is accepting applications for PhD students.

Sergey Nejentsev is available for consultancy.


Research Interests

We are searching for genes in the human genome that carry sequence variants, which are involved in resistance to infection and predispose to infectious diseases. Discovery of such genes can open new biological pathways and suggest new targets for intervention. We use methods of human genetics, including genome-wide association studies (GWAS) and exome sequencing, in vitro models of infection and methods of molecular biology to understand underlying biological mechanisms protecting from infection.

Key Publications

Angulo I, Vadas O, Garçon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers E, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A*, Nejentsev S*. Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage. Science. 2013 Oct 17. *shared senior authors

Burns SO, Zenner, HL, Plagnol, V, Curtis, J, Mok, K, Eisenhut, M, Kumararatne, D, Doffinger, R, Thrasher, AJ, _Nejentsev, S: LRBA gene deletion in a patient presenting with autoimmunity without hypogammaglobulinemia. J Allergy Clin Immunol, 2012; 130:1428-32.

Plagnol V, Curtis J, Epstein M, Mok K, Stebbings E, Grigoriadou S, Wood NW, Hambleton S, Burns SO, Thrasher A, Kumararatne D, Doffinger R, Nejentsev S: A robust model for read count data in exome sequencing experiments and implications for copy number variant calling. Bioinformatics 28:2747-54, 2012

Thye T, Owusu-Dabo E, Vannberg FO, van Crevel R, Curtis J, Sahiratmadja E, Balabanova Y, Ehmen C, Muntau B, Ruge G, Sievertsen J, Gyapong J, Nikolayevskyy V, Hill PC, Sirugo G, Drobniewsk F, van de Vosse E, Newport M, Alisjahbana B, Nejentsev S, Ottenhoff THM, Hill AVS, Horstmann RD, Meyer CG: Common variants at 11p13 are associated with susceptibility to tuberculosis. Nat Genet 44:257-9, 2012

Nejentsev S, Walker N, Riches D, Egholm M, Todd JA:Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes. Science 324: 387-9, 2009

Nejentsev S, Howson JMM, Walker NM, Szeszko JS, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LMM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA and The Wellcome Trust Case Control Consortium: Localisation of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450: 887-92, 2007