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Dr Tim Halim

Research Interests

I study the role of Group 2 Innate Lymphocytes (ILC2) in the immune response to inhaled allergens. We have previously shown that ILC2 are critical for the initiation of acute allergic lung inflammation. We now also demonstrate the important role of ILC2 in facilitating the adaptive immune response. Future work on dissecting the mechanism(s) by which ILC2 regulate the overall immune response may lead to novel therapeutics, or more efficient therapeutic interventions.

Keywords

group 2 innate lymphoid cells (ILC2) ; Th2 ; type-2 inflammation ; natural helper cells ; Th2 cells ; cytokines

Topics

  • allergies
  • allergy

Key Publications

Halim TY, Hwang YY, Scanlon ST, Zaghouani H, Garbi N and McKenzie ANJ. (2015) Group 2 innate lymphoid cells license dendritic cells to potentiate memory Th2 cell responses. Nat Immunol 17(1): 57-64.

 

Halim TY. (2015) Group 2 innate lymphoid cells in disease. Int Immunol (10.1093/intimm/dxv050)

 

Halim TY, Steer CA, Mathä L, Gold MJ, Martinez-Gonzalez I, McNagny KM, McKenzie, ANJ and Takei F.  (2014) Group 2 Innate Lymphoid cells are critical for the initiation of adaptive T helper 2 cell mediated allergic lung inflammation. Immunity 40(3): 425-435.

 

Gold MJ, Antignano F, Halim TY (co-2nd author), Hirota JA, Zaph C, Takei F and McNagny KM. (2014) Group 2 Innate Lymphoid cells facilitate allergic airway inflammation in response to local but not systemic Th2-inducing allergen exposures. J Allerg Clin Immunol. 133(4):1142-1148.

 

Halim TY and Takei F. (2014) Isolation and Characterization of Mouse Innate Lymphoid Cells. Curr Protoc Immunol. 106:IV:3.25:3.25.1–3.25.13.

 

Halim TY and McKenzie ANJ. (2013) New kids on the block: group 2 innate lymphocytes and type-2 inflammation of the airways. Chest. 144(5): 1681-1686.

 

Halim TY, MacLaren A, Romanish MT, Gold MJ, McNagny KM and Takei F. (2012) Retinoic acid receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. Immunity 37(3):463-474.

 

Halim TY, Krauß RH, Sun AC and Takei F. (2012) Lung natural helper cells are critical source of Th2 cytokines in protease allergen-induced airway inflammation. Immunity 36(3): 451-463.

 

Petriv OI, Kuchenbauer F, Delaney AD, Lecault V, White A, Kent D, Marmolejo L, Heuser M, Berg T, Copley M, Ruschmann J, Sekulovic S, Benz C, Kuroda E, Ho V, Antignano F, Halim TY, Giambra V, Krystal G, Takei F, Weng AP, Piret J, Eaves C, Marra MA, Humphries RK, Hansen CL. (2010) Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci USA. 107(35): 15443-8.

 

Veinotte LL, Halim TY (co-1st author) and Takei F. (2008) Unique subset of natural killer cells develop from progenitors in lymph node. Blood 111(8): 4201-4208.

 

Halim TY, Lavoie JC, Barnett MJ, Forest DL, Hogge DE, Nantel SH, Nevill TJ,  Shepherd JD, Song KW, Sutherland HJ, Toze CL, and Smith CA (2007) High Risk AML Outpatient Management: A Retrospective Analysis of Septicemia Incidence Following Chemotherapy. Ann Oncol (7): 1246-1252.