skip to primary navigationskip to content

The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.

last modified Sep 15, 2015 01:56 PM
Christopher Rudd and colleagues have recently had a paper published in Molecular Cell on a new pathway that regulates T-cell activation.

It is a new way of viewing signaling in T-cells, directly at the compartmentalized level of the nuclear pore complex (NPC). 40-50% of all NFATc1 and NFkb nuclear entry in T-cells is controlled by this new pathway.
Liu H, Schneider H, Recino A, Richardson C, Goldberg MW, Rudd CE.

Mol Cell. 2015 Aug 26. pii: S1097-2765(15)00573-0. doi:
10.1016/j.molcel.2015.07.015

Please click here to access the paper

Upcoming events

Antibody Technologies and Therapeutics Conference

Sep 10, 2017

Monash University Conference Centre Prato , Italy

Exploring Human Host-Microbiome Interactions in Health and Disease

Sep 13, 2017

Wellcome Conference Centre, Hinxton

Entrepreneurs in Clinical Academia (ECA) course

Oct 16, 2017

INSEAD, Fontainebleau, France

Upcoming events

The new Capella building- CITIID

See the home of CITIID being built in this fantastic time-lapse video. From basement to water tight in 17 months. The Capella building will be finished in 2018.

FCEs provide interdisciplinary training programmes for students, fellows and continuing education physicians through FOCIS assisted opportunities

Read more