It is a new way of viewing signaling in T-cells, directly at the compartmentalized level of the nuclear pore complex (NPC). 40-50% of all NFATc1 and NFkb nuclear entry in T-cells is controlled by this new pathway.
Liu H, Schneider H, Recino A, Richardson C, Goldberg MW, Rudd CE.
Mol Cell. 2015 Aug 26. pii: S1097-2765(15)00573-0. doi:
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