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The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.

last modified Sep 15, 2015 01:56 PM
Christopher Rudd and colleagues have recently had a paper published in Molecular Cell on a new pathway that regulates T-cell activation.

It is a new way of viewing signaling in T-cells, directly at the compartmentalized level of the nuclear pore complex (NPC). 40-50% of all NFATc1 and NFkb nuclear entry in T-cells is controlled by this new pathway.
Liu H, Schneider H, Recino A, Richardson C, Goldberg MW, Rudd CE.

Mol Cell. 2015 Aug 26. pii: S1097-2765(15)00573-0. doi:
10.1016/j.molcel.2015.07.015

Please click here to access the paper