skip to primary navigationskip to content

The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.

last modified Sep 15, 2015 01:56 PM
Christopher Rudd and colleagues have recently had a paper published in Molecular Cell on a new pathway that regulates T-cell activation.

It is a new way of viewing signaling in T-cells, directly at the compartmentalized level of the nuclear pore complex (NPC). 40-50% of all NFATc1 and NFkb nuclear entry in T-cells is controlled by this new pathway.
Liu H, Schneider H, Recino A, Richardson C, Goldberg MW, Rudd CE.

Mol Cell. 2015 Aug 26. pii: S1097-2765(15)00573-0. doi:
10.1016/j.molcel.2015.07.015

Please click here to access the paper

Upcoming events

Your personal immune army

Mar 26, 2017

Cambridge Biomedical Campus, UTC Cambridge Robinson Way Cambridge CB2 0SZ, CB2 0SZ

The Ageing Cell Conference 2017

Mar 27, 2017

The Babraham Institute

Cells as Models of Disease and New Therapeutics

Mar 29, 2017

Homerton College, in Cambridge,

Cambridge Immunology PhD and Postdoc Day 2017

Jun 08, 2017

Cancer Research UK, Cambridge Institute

Upcoming events

FCEs provide interdisciplinary training programmes for students, fellows and continuing education physicians through FOCIS assisted opportunities

Read more