Dr Elena Vigorito

University position

Group Leader

Dr Elena Vigorito is pleased to consider applications from prospective PhD students.

Research Themes

Cellular immune responses and immune regulation

Immunogenetics

Departments

Laboratory of Lymphocyte Signalling and Developnment

Institutes

Babraham Institute

Email

Home page

http://www.babraham.ac.uk/lym... (personal home page)

Interests

Our main goal is to understand how immune cells make important decisions relative to proliferation, differentiation or apoptosis. These events are the basis for lasting immunological protection which underpins effective vaccination. Understanding these processes is also not only fundamental for public health but also for treating autoimmunity and cancer. The emergence of miRNAs as regulators of gene expression and their potential role as tumour suppressors or oncogenes is likely to have an impact on gene therapies designed to block tumour progression. Understanding how the expression of miRNAs is regulated, which cellular function they influence and the identification of their molecular targets under normal conditions is therefore essential to identify their role in cancer. We address these questions by using an integrative approach combining cellular biology, biochemical and bioinformatics methodologies to provide mechanistic insights on miRNA function in the immune system.

Research Focus

Pathogens

None indicated

Equipment

Key publications

Turner M, Vigorito E (2008), ““Regulation of B- and T-cell differentiation by a single microRNA. Biochem Soc Trans””, 36(Pt 3):531 3:

Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M, (2007) microRNA-155 regulates the generation of immunoglobulin class-switched plasma

cells. Immunity. 27:847–59.

Rodriguez A*, Vigorito E*, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A, (2007) Requirement of bic/microRNA-155 for normal immune function. Science. 316:608–11. * equal contribution

Vigorito E, Kovesdi D, Turner M (2006) Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCγ.

Cellular Signalling 18 1455–1460

Hebeis B*, Vigorito E*, Kovesdi D, Turner M (2005)

Vav proteins are required for B-lymphocyte responses to LPS.

Blood 106 635–640 * Authors contributed equally

Vigorito E, Gambardella L, Colucci F, McAdam S, Turner M (2005)

Vav proteins regulate peripheral B-cell survival.

Blood 106 2391–2398

Collaborators

No collaborators listed

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