Research Associate - Cardiff University - Division of Infection and Immunity, School of Medicine
Cardiff University - Division of Infection and Immunity, School of Medicine
The Division of Infection & Immunity and the Systems Immunity Research Institute at Cardiff University School of Medicine seek to appoint a Research Associate. The successful applicant will work in the research group of Dr Matthias Eberl and investigate how microbial pathogens are sensed by the human immune system and how they trigger acute inflammatory responses in individuals with microbial infections. The successful applicant will join a vibrant and well-funded research environment, which includes established investigators, post-doctoral fellows, PhD students and technical assistants.
Research in the group of Dr Eberl is based upon the premise that each type of infection evokes a distinct pathogen-specific host response (‘immune fingerprint’), and that specialised types of innate-like T cells sense distinct groups of pathogens and orchestrate local inflammatory responses at sites of infection. These specificities can be exploited for targeted therapies and point-of-care tests for infection diagnosis.
The position is funded for 3 years by a Medical Research Council grant awarded to a multidisciplinary team led by Dr Eberl involving Prof Donald Fraser (peritoneal dialysis), Prof Philip Taylor (myeloid cell biology), Prof David Price and Dr Kristin Ladell (TCR clonotyping) and Prof Jamie Rossjohn (structure/function relationships).
This vacancy is for a Research Associate who will contribute to the definition of local and systemic responses of unconventional human T cells in individuals before, during and after acute peritonitis caused by a range of bacterial species; to the identification of antigen-presenting cells in the peritoneal cavity that present microbial ligands to such unconventional T cells; and to the definition of the molecular principles underlying the recognition of distinct microorganisms by human unconventional T cells. Experimental techniques employed will include multi-colour flow cytometry, cell sorting, T cell receptor clonotyping and functional characterisations of unconventional T cell responses to microbial pathogens in cell culture.
The post-holder will work across disciplinary boundaries, in close collaboration with microbiologists, immunologists, statisticians and clinicians, embedded in all-Wales, UK-wide and international academic and clinical networks.
Successful applicants are expected to have a PhD in Immunology or in a relevant Biomedical Sciences subject.
Interested parties are encouraged to contact Dr Matthias Eberl ( firstname.lastname@example.org ) for an informal discussion.
For further information on the research environment please visit:
This post is full time (35 hours per week) and is fixed term for 3 years.
Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.
Cardiff University is committed to supporting and promoting equality and diversity. Our inclusive environment welcomes applications from talented people from diverse backgrounds.