Research
I have focused my research on the design and preclinical evaluation of new drugs for restoring immune tolerance in rheumatoid arthritis and type 1 diabetes. Specifically, I have studied mechanisms of Treg-mediated bystander suppression induced by peptides derived from HSP in ex vivo human assays and in animal models.
Publications
Lorenzo N, Cantera D, Barberá A, Alonso A, Chall E, Franco L, Ancizar J, Nuñez Y, Altruda F, Silengo L, Padrón G, Dominguez MC. APL-2, an altered peptide ligand derived from heat-shock protein 60, induces interleukin-10 in peripheral blood mononuclear cell derived from juvenile idiopathic arthritis patients and downregulates the inflammatory response in collagen-induced arthritis model. Clin Exp Med. 2014.
Barberá A, Lorenzo N, Garrido G, Mazola Y, Falcón V, Torres AM, Hernández MI, Hernández MV, Margry B, de Groot AM, van Roon J, van der Zee R, Broere F, van Eden W, Padrón G, Domínguez MC. APL-1, an altered peptide ligand derived from human heat-shock protein 60, selectively induces apoptosis in activated CD4+ CD25+ T cells from peripheral blood of rheumatoid arthritis patients. Int Immunopharmacol. 2013 Dec;17(4):1075-83.
Dranguet J, Fraga A, Díaz MT, Mallok A, Viebahn-Hänsler R, Fahmy Z, Barberá A, Delgado L, Menéndez S and León OS. Ozone oxidative post conditioning ameliorates joint damage and decreases pro-inflammatory cytokine levels and oxidative stress in PG/PS-induced arthritis in rats. European Journal of Pharmacology 2013; 714: 318–324.
Lorenzo N, Barberá A, Domínguez MC, Torres AM, Hernández MV, Hernández I, Gil R, Ancizar J, Garay H, Reyes O, Altruda F, Silengo L and Padrón G. Therapeutic effect of and altered peptide ligand derived from human Hsp60 by suppressing of inflammatory cytokines secretion in two animal models of rheumatoid arthritis. Autoimmunity 2012;45(6):449-59.
Domínguez MC, N. Lorenzo, Barberá A, G. Darrasse-Jeze, N. López, MV. Hernández AM Torres, Hernández I, Gil R, Klatzmann D and Padrón G. An altered peptide ligand corresponding to a novel epitope from heat-shock protein 60 induces regulatory T cells and suppresses pathogenic response in an animal model of adjuvant induced arthritis. Autoimmunity 2011; 44 (6): 471-482.
Patents
Use of APL-Type peptide for treating intestinal inflammatory diseases and type 1 diabetes. PCT/CU2009/000009. A Barberá, MC Domínguez, N Lorenzo, V Falcón, I Menéndez and G Padrón. Granted in Europe, Australia, Argentina, EUA.
Peptides and their derived type APL of the HSP60 and pharmaceutical compositions. PCT/CU2005/000008. MC Domínguez, G. Padrón, N. López, N. Lorenzo, A. Barberá, A. Hernández, V. Morera, C. Cosme, N. Merino, A. Vázquez, J. Suárez. Granted in Russia, Australia, South Korea, Argentina, Europe and EUA.
