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Dr Julia Rolf

Research Interests

My research is focused on signalling in lymphocytes and more specifically the role of the PI3K pathway in T-B cell interactions during an immune response. Since PI3K is known to be involved in many cellular process, we are using conditional deletion of the P110d catalytic subunit as an approach to study how PI3K activity regulates lymphocyte differentiation and functions.

Keywords

germinal center ; co-stimulation ; T helper cells ; B cells ; T lymphocyte ; activation ; co-stimulatory molecules ; T cells ; affinity maturation ; phosphorylation ; antibody responses ; animal models ; cytokine/interleukin/chemokine receptors ; signalling ; T cell receptor (TCR) ; helper T cells

Key Publications

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.Soond DR, Garçon F, Patton DT, Rolf J, Turner M, Scudamore C, Garden OA, Okkenhaug K. J Immunol. 2012 Jun 15;188(12):5935-43

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. Rolf J. Bell SE, Kovesdi D, Janas ML, Soond DR, Webb LM, Santinelli S, Saunders T, Hebeis B, Killeen N, Okkenhaug K, Turner M. J Immunol. 2010 Oct 1;185(7):4042-52.

Rolf J, Fairfax K, Turner M. Signaling pathways in T follicular helper cells. J Immunol. 2010 Jun 15;184(12):6563-8.