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Judith Kraiczy

Judith Kraiczy

Office Phone: 01223 217 553

Departments

Department of Paediatrics :
Research Associate

Research Interests

My research focus lies on epigenetic mechanisms in the intestinal epithelium. I am interested in the role of DNA methylation during intestinal development and how it affects regionalization by regulating gene expression. Furthermore, I investigate alterations in the gut epithelium in Inflammatory Bowel Disease using primary cells and human organoid models.

Keywords

development ; epigenetics ; gastroenterology ; epithelial cells ; DNA methylation ; mucosal immunology ; paediatric gastroenterology ; gut

Topics

  • Ulcerative Colitis
  • 3D cell culture
  • gastroenterology
  • Crohn's disease
  • inflammatory bowel disease

Key Publications

Kraiczy, J., Nayak, K., Howell, K., Ross, A., Forbester, J., Salvestrini, C., Mustata, R., Perkins, S., Andersson-Rolf, A., Leenen, E., Liebert, A., Vallier, L., Rosenstiel, P., Stegle, O., Dougan, G., Heuschkel, R., Koo, B.-K. and Zilbauer, M. (2017) ‘DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development’, Gut, In press. doi: 10.1136/gutjnl -2017-314817

Howell, K. J. K., Kraiczy, J., Nayak, K., Gasparetto, M., Ross, A., Lee, C., Mak, T. N. T. N., Koo, B.-K. B.-K., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O. and Zilbauer, M. (2017) ‘DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome’, Gastroenterology, In press. doi: 10.1053/j.gastro.2017.10.007.

 Kraiczy, J., Nayak, K., Ross, A., Raine, T., Mak, T. N., Gasparetto, M., Cario, E., Rakyan, V., Heuschkel, R. and Zilbauer, M. (2016) ‘Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease’, Mucosal Immunology, 9(3), pp. 647–658. doi: 10.1038/mi.2015.88.

Other Publications

Zilbauer, M. and Kraiczy, J. (2017) ‘Epigenetics in Gastrointestinal Health and Disease: Spotlight on DNA Methylation in the Intestinal Epithelium’, in Nestle Nutrition Institute Workshop Series, pp. 35–44. doi: 10.1159/000455211.

Zilbauer, M., Zellos, A., Heuschkel, R., Gasparetto, M., Kraiczy, J., Postberg, J., Greco, L., Auricchio, R., Galatola, M., Embleton, N. N., Wirth, S. and Jenke, A. (2015) ‘Epigenetics in Paediatric Gastroenterology, Hepatology, and Nutrition: Present Trends and Future Perspectives.’, JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 62(4), pp. 521–9. doi: 10.1017/CBO9781107415324.004.

Tharp, K. M., Jha, A. K., Kraiczy, J., Yesian, A., Karateev, G., Sinisi, R., Dubikovskaya, E. A., Healy, K. E. and Stahl, A. (2015) ‘Matrix-assisted transplantation of functional beige adipose tissue’, Diabetes, 64(11), pp. 3713–3724. doi: 10.2337/db15-0728.

Kolodziejczak, D., Spanier, B., Pais, R., Kraiczy, J., Stelzl, T., Gedrich, K., Scherling, C., Zietek, T. and Daniel, H. (2013) ‘Mice lacking the intestinal peptide transporter display reduced energy intake and a subtle maldigestion/malabsorption that protects them from diet-induced obesity.’, AJP: Gastrointestinal and Liver Physiology, 304(10), pp. G897-907. doi: 10.1152/ajpgi.00160.2012.