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Dr Julia Maryam Arasteh

Departments

Department of Medicine:
Cambridge Immunology Network Coordinator

Research Interests

I obtained a BSc in Cellular and Molecular Biology and an MSc in Immunology from Shiraz University, finishing in 2006. I then undertook my PhD in the laboratory of Professor Ulrike Mayer at The University of East Anglia, during which I generated several mouse models to study Autophagy.  I later trained as a postdoc at The Sanger Institute in Cambridge in the laboratory of Dr Trevor Lawley where my research focused on the functional analysis of novel genes associated with inflammatory bowel disease (IBD) using knockout animal models generated through the Mouse Genetics Project.

Key Publications

Rai S, Arasteh M, Jefferson M, Pearson T, Wang Y, Zhang W, Bicsak B, Divekar D, Powell PP, Naumann R, Beraza N, Carding SR, Florey O, Mayer U, Wileman T. The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. Autophagy. 2019 Apr; 15 (4):599-612.

 

Schneditz G, Elias JE, Pagano E, Zaeem Cader M, Saveljeva S, Long K, Mukhopadhyay S, Arasteh M, Lawley TD, Dougan G, Bassett A, Karlsen TH, Kaser A, Kaneider NC. GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Sci Signal. 2019 Jan 1; 12 (562).

 

Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh JM, Mayer U, Carding SR, Wileman T, Beale R, Florey O. The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO J. 2018 Feb 15; 37(4).

 

Schreiber F, Arasteh JM, Lawley TD. Pathogen Resistance Mediated by IL-22 Signaling at the Epithelial-Microbiota Interface. J Mol Biol. 2015 Nov 20; 427 (23):3676-82. Review.

 

Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD, Browne HP, Keane JA, Page AJ, Kumasaka N, Kane L, Mottram L, Harcourt K, Hale C, Arends MJ, Gaffney DJ; Sanger Mouse Genetics Project, Dougan G, Lawley TD. Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen. Cell Host Microbe. 2014 Oct 8; 16 (4):504-16.

 

Arasteh JM, Sarvestani EK, Aflaki E, Amirghofran Z. Fas gene polymorphisms in systemic lupus erythematosus and serum levels of some apoptosis-related molecules. Immunol Invest. 2010; 39 (1):27-38.

 

Mucyn TS, Wu AJ, Balmuth AL, Arasteh JM, Rathjen JP. Regulation of tomato Prf by Pto-like protein kinases. Mol Plant Microbe Interact. 2009 Apr; 22 (4):391-401.