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Dr Anne-Katrien Stark

Research Interests

 

The Phosphoinositide 3-kinase (PI3K) family of lipid kinases play an important role in cell growth, development and function. Class 1 PI3K are heterodimeric proteins consisting of a regulatory and catalytic subunit, of which the p110α and p110β isoforms are ubiquitously expressed but the p110δ and p110γ isoforms are more restricted to immune cells. Inappropriate immune responses directed against self-antigens, or excessive inflammation during a response to infection can cause debilitating disease and death. The PI3K p110δ play an important role in both pro-inflammatory and regulatory immune responses.  My research focus on the effects of p110δ inhibition on the immune response in the context of disease models of infection (Streptococcus pneumoniae) and autoimmunity (Experimental Autoimmune Encephalitis (EAE)) through the use of specific small molecule inhibitors and kinase-dead knock-in mice.

 

 

Keywords

T cell differentiation ; EAE. ; p110δ ; PI3K

Topics

  • autoimmunity
  • streptococcus pneumonia

Key Publications

Bermudez-Fajardo A, Stark AK, El-Kadri R, Penichet ML, Hölzle K, Wittenbrink MM, Hölzle L, Oviedo-Orta E. The effect of Chlamydophila pneumoniae Major Outer Membrane Protein (MOMP) on macrophage and T cell-mediated immune responses.Immunobiology. 2011 Jan-Feb;216(1-2):152-63.