Research
Development of vaccines targeting Dendritic cells and DC-based cancer immunotherapy. Specifically utilisation of heat shock protein complexes and Fc-tags to target antigens to DC for activation of both innate and acquired immune responses
Publications
Key publications:
Hill S, Entwisle C, Pang Y, Joachim M, McIlgorm A, Dalton K, Burbidge P, Colaco C, Brown J, Goldblatt D, Bailey C Immunogenicity and mechanisms of action of PnuBioVax, a multi-antigen serotype-independent prophylactic vaccine against infection with Streptococcus pneumoniae. (2018) Vaccine. 5, 4255-4264.
Entwisle C, Hill S, Pang Y, Joachim M, McIlgorm A, Colaco C, Goldblatt D, De Gorguette D'Argoeuves P, Bailey C. Safety and immunogenicity of a novel multiple antigen pneumococcal vaccine in adults: A Phase 1 randomised clinical trial. (2017) Vaccine. 18, 7181-7186.
Ng GZ, Han JX, Colaco CA, Sutton P. Activation of TRIF-dependent and independent immune responses by neisseria heat shock protein complex vaccines. (2016) Human Vaccine Immunotherapy. 12, 2797-2800.
Han JX, Ng GZ, Cecchini P, Chionh YT, Saeed MA, Naess LM, Joachim M, Blandford LE, Strugnell RA Colaco CA, Sutton P. Heat shock protein complex vaccines induce antibodies against Neisseria meningitidis via a MyD88-independent mechanism. (2016) Vaccine. 29, 1704-11.
Colaco CA, Bailey CR, Walker KB, Keeble J. Heat shock proteins: stimulators of innate and acquired immunity. Biomed Res Int. 2013;2013:461230.
McNulty S, Colaco CA, Blandford LE, Bailey CR, Baschieri S, Todryk S. Heat shock proteins as dendritic cell-targeting vaccines - getting warmer. Immunology. 2013 Apr 2
Colaco C. Autologous heat-shock protein vaccines. Human Vacc. Immunother. (2013) 9, 1-2.
Loureiro S., Ren J., Phapugrangkul P., Colaco C.A., Bailey C.R., Shelton H., Molesti E., Temperton N.J., Barclay W.S. and Jones I.M. Adjuvant free immunisation with Hemagglutinin-Fc fusion proteins as an approach to influenza vaccines. J Virol. (2011) 85, 3010-3014.
Wright D.E, Colaco S., Colaco C. & Stevenson P.G. Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions. J. Gen. Virol. (2009) 90, 2592-2603
Colaco C.A.L.S. Cancer Immunotherapy, simply cell biology. Molecular Medicine Today (2003). 12, 515-516.
Colaco C.A.L.S. Why DCs are central to cancer immunotherapy. Molecular Medicine Today (1999). 5, 14-17.
Colaco C.A.L.S. Towards a Unified Theory of Immunity; DCs, stress proteins and antigen capture. Cell.Mol.Biol. (1998) 6, 883-890.
