skip to primary navigationskip to content
 

Debbie Smyth

Research Associate


Research Interests

Our aim is to further characterise the molecular basis of type 1 diabetes. We use a combination of genetics, statistics, genome informatics and data mining, and gene expression and immunological studies.  Our major goal now is to correlate susceptibility genotypes with biomarkers and phenotypes.  Immunological studies are underpinning the next major phase of our research beginning in 2013: undertaking clinical studies and trials in patients with type 1 diabetes.

Keywords

genetic analysis ; clinical trials

Topics

  • type I diabetes
  • autoimmunity

Key Publications

Howson JM, Krause S, Stevens H, Smyth DJ, Wenzlau JM, Bonifacio E, Hutton J, Ziegler AG, Todd JA, Achenbach P. Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases. Diabetologia. 2012 Jul;55(7):1978-84.

Wallace C, Rotival M, Cooper JD, Rice CM, Yang JH, McNeill M, Smyth DJ, Niblett D, Cambien F; Cardiogenics Consortium, Tiret L, Todd JA, Clayton DG, Blankenberg S. Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Hum Mol Genet. 2012 Jun 15;21(12):2815-24.

Davison LJ, Wallace C, Cooper JD, Cope NF, Wilson NK, Smyth DJ, Howson JM, Saleh N, Al-Jeffery A, Angus KL, Stevens HE, Nutland S, Duley S, Coulson RM, Walker NM, Burren OS, Rice CM, Cambien F, Zeller T, Munzel T, Lackner K, Blankenberg S; Cardiogenics Consortium, Fraser P, Gottgens B, Todd JA, Attwood T, Belz S, Braund P, Cambien F, Cooper J, Crisp-Hihn A, Diemert P, Deloukas P, Foad N, Erdmann J, Goodall AH, Gracey J, Gray E, Gwilliams R, Heimerl S, Hengstenberg C, Jolley J, Krishnan U, Lloyd-Jones H, Lugauer I, Lundmark P, Maouche S, Moore JS, Muir D, Murray E, Nelson CP, Neudert J, Niblett D, O'Leary K, Ouwehand WH, Pollard H, Rankin A, Rice CM, Sager H, Samani NJ, Sambrook J, Schmitz G, Scholz M, Schroeder L, Schunkert H, Syvannen AC, Tennstedt S, Wallace C. Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Hum Mol Genet. 2012 Jan 15;21(2):322-33.

Saleh NM, Raj SM, Smyth DJ, Wallace C, Howson JM, Bell L, Walker NM, Stevens HE, Todd JA. Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes. Diabetes Metab Res Rev. 2011 Nov;27(8):838-43.

Smyth DJ, Cooper JD, Howson JM, Clarke P, Downes K, Mistry T, Stevens H, Walker NM, Todd JA. FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection. Diabetes. 2011 Nov;60(11):3081-4.

Howson JM, Rosinger S, Smyth DJ, Boehm BO; ADBW-END Study Group, Todd JA. Genetic analysis of adult-onset autoimmune diabetes. Diabetes. 2011 Oct;60(10):2645-53.