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Dr El Kahina Meziane


Department of Pathology:
Research associate

Research Interests

I am curently interested in chicken MHC, and potential vaccination strategies in chickens.


co-stimulation ; B cells ; co-stimulatory molecules ; anergy ; natural killer cells ; cytokine/interleukin/chemokine receptors ; interleukin ; cytokines ; B cell receptor (BCR) ; T cell receptor (TCR) ; tolerance ; cytotoxic T cells (CTL) ; apoptosis ; activation ; T cells ; human studies ; antibody responses ; animal models ; suppression ; natural killer receptors ; cytotoxicity ; lectins ; cell development ; stem cells


  • vaccines
  • therapy
  • immunotherapy
  • cancer

Key Publications

Lomonosov M, Meziane el K, Ye H, Nelson DE, Randle SJ, Laman H. Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis. PLoS One. 2011;6(6):e21165. Epub 2011 Jun 17.

Meziane el K, Randle SJ, Nelson DE, Lomonosov M, Laman H. Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.J Cell Sci. 2011 Jul 1;124(Pt 13):2175-86

Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane el K, McDonald NQ. Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. J Biol Chem. 2008 Aug 8;283(32):22325-35.

Meziane el K, Bhattacharyya T, Armstrong AC, Qian C, Hawkins RE, Stern PL, Dermime S. Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma. Int J Cancer. 2004 Oct 10;111(6):910-20.

Dermime S, Gilham DE, Shaw DM, Davidson EJ, Meziane el-K, Armstrong A, Hawkins RE, Stern PL. Vaccine and antibody-directed T cell tumour immunotherapy. Biochim Biophys Acta. 2004 Jul 6;1704(1):11-35.