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Dr John Deighton

Research Interests

The mechanism of allergic disease, particularly Bee and Wasp venom allergy. Using, electrophoresis and immunoglobulin and cytokine ELISA's.

Keywords

protein purification ; enzyme assays ; microscopy ; electrophoresis ; venom ; hypersensitivity ; ELISA's ; interleukin ; cytokines

Topics

  • allergy

Key Publications

Katherine Anagnostou , Sabita Islam, Yvonne King , Loraine Foley, Laura Pasea , Simon Bond ,Chris Palmer , John Deighton , Pamela Ewan, Andrew Clark Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial The Lancet, Early Online Publication, 30 January 2014

Clark A, Mangat J, King Y, Islam S, Anagnostou K, Foley L, Deighton J, Ewan P. Thermographic imaging during nasal peanut challenge may be useful in the diagnosis of peanut allergy. Allergy. 2012 Apr;67(4):574-6.

Clark A, Islam S, King Y, Deighton J, Szun S, Anagnostou K, Ewan P. A longitudinal study of resolution of allergy to well-cooked and uncooked egg. Clin Exp Allergy. 2011 May;41(5):706-12.

Anagnostou K, Clark A, King Y, Islam S, Deighton J, Ewan P. Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome. Clin Exp Allergy. 2011 Sep;41(9):1273-81.

Clark AT, Islam S, King Y, Deighton J, Anagnostou K, Ewan PW. Successful oral tolerance induction in severe peanut allergy. Allergy. 2009 Aug;64(8):1218-20.

Tay SS, Clark AT, Deighton J, King Y, Ewan PW. T cell proliferation and cytokine responses to ovalbumin and ovomucoid detected in children with and without egg allergy. Clin Exp Allergy. 2007 Oct;37(10):1519-27.

Tay SS, Clark AT, Deighton J, King Y, Ewan PW.Patterns of immunoglobulin G responses to egg and peanut allergens are distinct: ovalbumin-specific immunoglobulin responses are ubiquitous, but peanut-specific immunoglobulin responses are up-regulated in peanut allergy. Clin Exp Allergy. 2007 Oct;37(10):1512-8.