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Dr Jonathan Dodd

Research Interests

My research is focussed on design of novel, long-lived IL-2 delivery vectors that expand regulatory T cell (Treg) populations in vivo and inhibit Type 1 diabetes (T1D) development. T1D is an autoimmune disease in which insulin-producing β-cells located in pancreatic islets are selectively destroyed by the immune system, eventually resulting in β-cell loss, insulin deficiency and hyperglycaemia. T1D progression is associated with a temporal loss in the capacity of Tregs to expand & survive in β-islets, which in turn disrupts the regulatory T cell:effector T cell balance and unleashes anti-islet immune responses. IL-2 is critical for Treg generation and expansion, and in the non obese diabetic (NOD) mouse model of T1D, IL-2 administration increased Treg cell survival and decreased the incidence of T1D.

Keywords

mucosal immunology

Topics

  • lung immunology
  • type 1 diabetes

Collaborators

Key Publications

Dodd JS, Clark D, Muir R, Korpis C, Openshaw PJ. Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV disease in mice. Mucosal Immunol. 2013 Jul;6(4):704-17. 

Wythe SE, Dodd JS, Openshaw PJ, Schwarze J. OX40 ligand and programmed cell death 1 ligand 2 expression on inflammatory dendritic cells regulates CD4 T cell cytokine production in the lung during viral disease. J Immunol. 2012 Feb 15;188(4):1647-55.
Dodd JS, Lum E, Goulding J, Muir R, Van Snick J, Openshaw PJ. IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection. J Immunol. 2009 Dec 1;183(11):7006-13.
Dodd J, Riffault S, Kodituwakku JS, Hayday AC, Openshaw PJ. Pulmonary V gamma 4+ gamma delta T cells have proinflammatory and antiviral effects in viral lung disease. J Immunol. 2009 Jan 15;182(2):1174-81.

Culley FJ, Pennycook AM, Tregoning JS, Dodd JS, Walzl G, Wells TN, Hussell T, Openshaw PJ. Role of CCL5 (RANTES) in viral lung disease. J Virol. 2006 Aug;80(16):8151-7.