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Dr Keith Boyle

Research Interests

I am interested in cell autonomous immunity, in particular anti-bacterial autophagy and immune signalling.

Keywords

neutrophils ; autophagy ; immune signalling ; cell autonomous immunity

Key Publications

Boyle KB, Stephens LR, Hawkins PT. Activation of the neutrophil NADPH oxidase by Aspergillus fumigatus. Ann N Y Acad Sci. 2012 Dec;1273:68-73.

Juss JK, Hayhoe RP, Owen CE, Bruce I, Walmsley SR, Cowburn AS, Kulkarni S, Boyle KB, Stephens L, Hawkins PT, Chilvers ER, Condliffe AM. Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival. PLoS One. 2012;7(9):e45933.

Boyle KB, Gyori D, Sindrilaru A, Scharffetter-Kochanek K, Taylor PR, Mócsai A, Stephens LR, Hawkins PT. Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol. 2011 Mar 1;186(5):2978-89.

Boyle KB, Hadaschik D, Virtue S, Cawthorn WP, Ridley SH, O'Rahilly S, Siddle K. The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation. Cell Death Differ. 2009 May;16(5):782-9.

Anderson KE, Boyle KB, Davidson K, Chessa TA, Kulkarni S, Jarvis GE, Sindrilaru A, Scharffetter-Kochanek K, Rausch O, Stephens LR, Hawkins PT. CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks. Blood. 2008 Dec 15;112(13):5202-11.