Dr Krzysztof Kolmus

My research focuses at developing a complete antagonist(s) of an innate immune receptor. I take advantage of various cell-based approaches to screen a large library of compounds in order to select the most potent and non-cytotoxic ligands. Using structural biology methods, I want to confirm direct interaction between these molecules and receptor. In parallel, direct interactors active in the low concentrations will be chemically modified to improve their antagonistic parameters.