Research
I am an Immunology post-doc with a research interest in tolerance, immune regulation and autoimmune/inflammatory diseases.
I undertook my PhD and first post-doc in Prof Hill Gaston's lab characterizing a novel subset of CD8+ regulatory T cells in patients with arthritis and other inflammatory diseases. More recently I worked in Ken Smith's lab on various projects relating to immune regulation and autoimmune models of disease.
As lab manager in Ken's lab I also took on a wider immunological interest as temporary Cambridge Immunolgy Coordinator for the Immunology Network prior to the appointment of Dr Tennie Videler, and enjoyed being involved in the running of the Immunology & Medicine seminar series and annual Cambridge Immunology Forum. I am currently taking a career break for childcare puropses.
Publications
Clatworthy MR, Kettunen MI, Hu DE, Mathews RJ, Witney TH, Kennedy BW, Bohndiek SE, Gallagher FA, Jarvis LB, Smith KG, Brindle KM.Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13374-9.
Kaur G, Goodall JC, Jarvis LB, Hill Gaston JS Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells--identification of Foxp3Δ7 in human regulatory T cells. Mol Immunol. 2010 48(1–3):321–32.
Gaston JS, Jarvis LB, Zhang L, Goodall JC. Dendritic cell: T-cell interactions in spondyloarthritis. Adv Exp Med Biol. 2009;649:263–76. Review. PubMed PMID: 19731636.
Zhang L, Jarvis LB, Baek HJ, Gaston JS. Regulatory IL4+CD8+ T cells in patients with ankylosing spondylitis and healthy controls. Ann Rheum Dis. 2009 68(8):1345–51.
Jarvis LB, Goodall JC, Gaston JS . Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells. Hum Immunol. 2008 69(11):687–95.
Baek HJ, Zhang L, Jarvis LB, Gaston JS. Increased IL-4+ CD8+ T cells in peripheral blood and autoreactive CD8+ T cell lines of patients with inflammatory arthritis. Rheumatology (Oxford) 2008 47(6):795–803.
Jarvis LB, Matyszak MK, Duggleby RC, Goodall JC, Hall FC, Gaston JS. Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function. Eur J Immunol. 2005 Oct;35(10):2896-908.
