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Dr Louise Bell

Departments

Cambridge Institute for Medical Research:
Research administrator

Research Interests

Managing research projects at the JDRF/Wellcome Trust Diabetes and inflammation Laboratory.  Our aim is to further characterise the molecular basis of type 1 diabetes. We use a combination of genetics, statistics, genome informatics and data mining, and gene expression and immunological studies.  Our major goal now is to correlate susceptibility genotypes with biomarkers and phenotypes.  Immunological studies are underpinning the next major phase of our research beginning in 2013: undertaking clinical studies and trials in patients with type 1 diabetes.

Topics

  • type I diabetes
  • influenza

Key Publications

Jagger BW, Wise HM, Kash JC, Walters KA, Wills NM, Xiao YL, Dunfee RL, Schwartzman LM, Ozinsky A, Bell GL, Dalton RM, Lo A, Efstathiou S, Atkins JF, Firth AE, Taubenberger JK, Digard P. (2012) An overlapping protein-coding region in influenza A virus segment 3 modulates the host response. Science 337 199-204.

Garg G, Tyler JR, Yang JH, Cutler AJ, Downes K, Pekalski M, Bell GL, Nutland S, Peakman M, Todd JA, Wicker LS, Tree TI. Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. J Immunol. 2012 May 1;188(9):4644-53

Saleh NM, Raj SM, Smyth DJ, Wallace C, Howson JM, Bell L, Walker NM, Stevens HE, Todd JA. Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes. Diabetes Metab Res Rev. 2011 Nov;27(8):838-43. doi: 10.1002/dmrr.1259.