skip to primary navigationskip to content
 

Dr Misty Jenkins

Research Interests

The focus of my research is to understand how cytotoxic T cells (CTL) contribute to clearance of virally infected and cancerous cells by understanding the mechanisms of polarised secretion of cytotoxic lysosomes.

I am currently in Australia.

Keywords

enzyme assays ; immunohistochemistry ; co-stimulatory molecules ; co-stimulation ; apoptosis ; activation ; calcium imaging ; T cells ; cell culture ; cell development ; signal transduction ; fluorescence microscopy ; confocal microscopy ; differentiation ; FACS ; signalling ; single cell PCR ; T cell receptor (TCR) ; granzymes/perforin/lysosomal

Topics

  • influenza
  • cancer
  • immunodeficiency
  • vaccines
  • immunodeficiency - primary
  • hepatitis C
  • immunodeficiency - secondary

Key Publications

Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R,Griffiths GM. Centrosome docking at the immunological synapse is controlled by Lck signaling. J Cell Biol. 2011 Feb 21;192(4):663-74.

Jenkins MR, and Griffiths GM, The synapse and cytolytic machinery of cytotoxic T cells. Current opinion in Immunology. 2010, 22:1 6

Jenkins MR, Tsun A, Stinchcombe JC, Griffiths GM. The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse. Immunity. 2009, 31, 621–631.

Jenkins MR, La Gruta NL, Doherty PC, Trapani JA, Turner SJ, Waterhouse NJ. Visualizing CTL Activity for Different CD8+ Effector T Cells Supports the Idea that Lower TCR/Epitope Avidity May be Advantageous for target cell killing. Cell Death and Differentiation. 2009. Apr;16(4):537–42.

Jenkins MR, Trapani JA, Doherty PC, Turner SJ. Granzyme K expressing CTL protect against influenza virus in granzyme AB-/- mice. Viral Immunology. 2008. 21 3, 341–346.

*Jenkins MR, Trapani JA, Doherty PC, Turner SJ. Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cells. Journal of Immunology. 2008. 181:3818–3822. *This article featured in the highlights section

A CTL polarising cytotoxic granules (red) towards the immunological synapse