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Dr Olympe Chazara


Office Phone: +44 (0)1223 333 728

Research Interests

In pregnancy, the maternal immune system is regulating placental development and function. The dominant population of uterine leukocytes are Natural Killer (NK) cells, able to recognise MHC Class-I molecules on fetal trophoblast cells. I work in the Moffett group which identified that one particular maternal KIR haplotype and fetal HLA-C combination is associated with the major diseases of pregnancy: recurrent miscarriage, fetal growth restriction, and pre-eclampsia. The question is now to refine the outcome of the different KIR genes/HLA ligands interactions.

Keywords

HLA-C ; KIR ; MHC ; MHC class I ; HLA

Topics

  • pre-eclampsia
  • reproductive immunology
  • recurrent miscarriage

Key Publications

Chazara   O.,   Xiong   S.,   Moffett   A.  Maternal   KIR   and   fetal   HLA-C:   A   fine   balance.   Journal   of   Leukocyte   Biology  2011 90,   703-16.  http://dx.doi.org/10.1189/jlb.0511227