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Cambridge Immunology Network

The complement system


My primary research interests include

  • The immunochemistry, biology and genetics of the complement system.
  • Microbial immunology. Particular topics include microbial subversion of the innate immune response and the immunology of measles.
  • Enhancement of the immune response and its relevance to vaccines.
  • Immunopathology, particularly in relation to systemic LE and to multiple sclerosis.
  • Parasite-driven diversity and selective pressures.
  • Insect sting allergies.


Selected posts held:

  • Founder President of the UK Academy of Medical Sciences (1998-2002)
  • Biological secretary of the Royal Society (1993-98)
  • President of the Royal College of Pathologists (1990-93)
  • served on UNESCO’s international bioethics committee from 1993-98.


Key publications: 

Ali YM, Hayat A, Saeed BM, Haleem KS, Alshamrani S, Kenawy HI, Ferreira VP, Saggu G, Buchberger A, Lachmann PJ, Sim RB, Goundis D, Andrew PW, Lynch NJ, Schwaeble WJ. Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5301-6.

Lachmann, PJ Preparing serum for functional complement assays. J Imm Methods 2010 352, 195-197

Lachmann PJ and Smith RAG Taking complement to the clinic – has the time finally come? Scand. J. Immunol. 2009 69 471-478

Lachmann, P Anti-infective antibodies – reviving an old paradigm. Vaccine 2009 27S, G33-G37

Lachmann, PJ The amplification loop of the complement pathways. Adv Imm 2009 104: 115-148

Fernie-King BA, Seilly DJ, Binks MJ, Sriprakash KS and Lachmann PJ Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities. Microbes Infect 2007 9 300-307

Manderson AP, Carlucci F, Lachmann PJ, Lazarus RA, Festenstein RJ, Cook HT, Walport MJ and Botto M  The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus. Arthritis Res Ther 2006 8(3) article no. R68

Other publications:

Professor Sir Peter  Lachmann
Not available for consultancy


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