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Dr Rupert Beale

Rupert Beale is available for consultancy.

Research Interests

I am interested in cell autonomous immunity, innate immune responses to exogenous nucleic acids and viruses.


autoimmunity ; signal transduction ; signalling ; RNA viruses ; DNA viruses


Key Publications

Rupert BealeHelen WiseAmanda Stuart,Benjamin J. Ravenhill,Paul DigardFelix Randow 2014 A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability Cell Host & Microbe, Volume 15, Issue 2, 239-247, 12 

Langlois MA, Beale RC, Conticello SG, Neuberger MS. Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities. Nucleic Acids Res. 2005 Apr 4;33(6):1913-23.

Neuberger MS, Di Noia JM, Beale RC, Williams GT, Yang Z, Rada C. Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation. Nat Rev Immunol. 2005 Feb;5(2):171-8.

Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS. Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. J Mol Biol. 2004 Mar 26;337(3):585-96.