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Dr Sara Lear

Research Interests

I'm a specialist registrar in clinical immunology. The department has an interest in innate immunity, B cell lineage and repertoire development; natural and vaccine induced immunity to streptococcus pneumonia in health and chronic disease.


B cell lineage and repertoire development ; innate immunity ; somatic hypermutation ; B cells


  • vaccines
  • autoimmunity
  • streptococcus pneumonia

Key Publications

Chua I, Standish R, Lear S, Harbord M, Eren E, Raeiszadeh M, et al. Anti-tumour necrosis factor-alpha therapy for severe enteropathy in patients with common variable immunodeficiency (CVID). Clinical and experimental immunology 2007, 150(2): 306-311.

Lear S, Eren E, Findlow J, Borrow R, Webster D, Jolles S. Meningococcal meningitis in two patients with primary antibody deficiency treated with replacement intravenous immunoglobulin. Journal of clinical pathology 2006, 59(11): 1191-1193.