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Dr Sarah Bell


Babraham Institute:
Senior Research Associate

Research Interests

My current research focusses on the role of RNA-binding proteins in lymphocyte development and function


immunohistochemistry ; B cell receptor (BCR) ; B cells ; PI3K ; cell surface molecules ; isotype switching ; immunoglobulins ; affinity maturation ; cell culture ; antibody responses ; animal models ; somatic hypermutation ; lymphocytes, ; FACS ; cell type


Key Publications

Rolf J, Bell SE, Kovesdi D, Janas ML, Soond DR, Webb LMC, Santinelli S, Saunders T, Hebeis B, Killeen N, Okkenhaug K, Turner M ()
Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction.  Journal of Immunology 2010 185 4042-4052

Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews SR, Li CM, Pannell R, Siebel CW, MacDonald HR, De Keersmaecker K, Ferrando AA, Grutz G, Turner M Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.  Nature Immunology 2010 11 717-724

Kovesdi D, Bell SE, Turner M The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K.  Self/Nonself 2010 1 144-153

Anouk Caraux, Nayoung Kim, Sarah E, Bell, Simona Zompi, Thomas Ranson, Sarah Lesjean-Pottier, Marcos E, Garcia-Ojeda, Martin Turner, and Francesco Colucci Phospholipase C-g2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells”, Blood 2006 107(3):994–1002

Sarah E, Bell, Maria Jose Sanchez, Olivera Spasic-Boskovic, Tomas Santalucia, Laure Gambardella, Graham J, Burton, John J, Murphy, John D, Norton Andrew R, Clark & Martin Turner The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression”, Developmental Dynamics 2006 235(11):3144–3155