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Cambridge Immunology Network

 

Research

I have done my PhD at NUIG, Ireland on the molecular mechanisms behind ER stress induced autophagy and induction of alternative cell death modalities. As a part of Kaser's group I am planning to apply my knowledge in these topics in order to understand how complex genetic and environmental alterations can be a cause of inflammatory bowel disease. 

Publications

Key publications: 

Saveljeva S, Mc Laughlin SL, Vandenabeele P, Samali A, Bertrand MJ, Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells, Cell Death Dis. 2015 Jan 8;6:e1587. 

Deegan S, Saveljeva S, Logue SE, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A, Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions, Autophagy. 2014 Nov 2;10(11):1921-36. (DS, SS and LSE contributed equally to the work)

Dr Svetlana  Saveljeva
Not available for consultancy

Affiliations

Classifications: 
Departments and institutes: 
Person keywords: 
cell biology
gastroenterology
apoptosis
autophagy
endoplasmic reticulum stress
cell processes
inflammation