Research
Our research interests lie at the interface of the tumour microenvironment, lymphatic biology and immunology. We believe the non-cancer cells comprising the stroma, especially those expressing a protein known as podoplanin, play an important role in helping to a) protect a new tumour from our immune system and b) develop and metastasise.
To understand how podoplanin expression within the tumour microenvironment is able to help drive tumour progression and modulation of the anti-tumour immune response, we take a multidisciplinary approach that integrates 3D co-culture systems, state-of-the-art microscopy techniques, genetically modified tumour models and in vivo imaging.
With the knowledge we gain, our ultimate goal is to develop therapeutic platforms that exploit these features to specifically target the tumour and supporting tissues.
Group members
Dr Luisa Pedro
Dr Angela Riedel
Bastian Schmied
Publications
Sarah Davidson, Mirjana Efremova, Angela Riedel, Bidesh Mahata, Roser Vento-Tormo, Jhuma Pramanik, Gozde Kar, Jani Huuhtanen, Jacqueline D. Shields*, Sarah A. Teichmann* (2020). Single cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment. Cell Reports. In Press.
Munir, H; Jones, JO; Janowitz, T; Martins, CP; Welsh SJ; Shields J (2020). Stromal Amyloid β drives Neutrophil extracellular trap formation to augment tumour growth. bioRxiv. doi:10.1101/2020.01.10.901686
Mahata, B. P., J.; Van der Weyden. L.; Kar, G.; Riedel, A.; Ryder, E.; Duddy, G.; Adams, DJ.; Shields, JD*.; Teichmann. SA* (2019). Tumors induce de novo steroid biosynthesis in T cells to evade immunity. bioRxiv. doi:https://doi.org/10.1101/2020.01.10.901686
Pedro L, Harmer Q, Mayes E, Shields JD (2019). Impact of Locally Administered Carboxydextran-Coated Super-Paramagnetic Iron Nanoparticles on Cellular Immune Function. Small. 15 (20) 1900224.
Ricardo Miragaia, Tomás Gomes, Agnieszka Chomka, Laura Jardine, Angela Riedel, Ahmed N Hegazy, Ida Lindeman, Guy Emerton, Thomas Krausgruber, Jacqueline Shields, Muzlifah Haniffa, Fiona Powrie, Sarah A Teichmann (2019). Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation. 5 Feb. Immunity. 50 (2) 493-504.
David Shorthouse, Angela Riedel, Emma Kerr, Luisa Pedro, Dora Bihary, Shamith Samarajiwa, Carla Martins, Jacqueline Shields*, Benjamin A Hall* (2018). Role of stromal osmoregulation in cellular transformation in cancer and disease. Nature Communications. 9(1):3011.
Tamara Muliaditan, Mary Okesola, Jonathan Caron, Mirella Georgouli, Peter Gordon, Sharanpreet Lall, Desislava Kuzeva, Luisa Pedro, Jacqueline D. Shields, Cheryl E. Gillett, Sandra S. Diebold, Victoria Sanz-Moreno, Tony Ng, Esther Hoste, and James N. Arnold (2018). Tumour-associated macrophages exploit an innate wound healing response to facilitate metastasis. Nature Communications. 9(1):2951.
M Lakins, E Ghorani, H Munir, C Martins, JD Shields (2018). Cancer-associated Fibroblasts Provide Immune Protection to Tumor Cells via Antigen-Specific Deletion of CD8+ Cytotoxic T Cells. Nature Communications.. 9: 948.
A Riedel, D Shorthouse, BA Hall, JD Shields (2016). Tumor induced stromal reprogramming drives lymph node transformation. Nature Immunology. 17(9): 1118–1127.
* Co-corresponding Author
