skip to primary navigationskip to content
 

Dr Sabita Islam

Research Interests

I am interested in understanding the mechanisms responsible for the restoration of natural or induced tolerance in children with food allergy. In vitro studies focus on changes in humoral and cellular immunity during resolution or persistence of clinical allergy. Data on immunoglobulin levels (IgE, IgG), allergens–specific T cell responses, regulatory T (Treg) cells, T-helper cytokines and basophil responses are investigated as potential biomarkers of clinical tolerance.

Keywords

allergen-specific T helper cells ; peanut ; regulatory T cells ; immunoglobulins ; flow cytometry ; immunotherapy ; IgG ; IgE ; oral tolerance ; biomarkers ; basophils ; ELISA's ; CFSE ; egg ; cytokines

Topics

  • allergy
  • food allergy
  • anaphylaxis

Key Publications

Katherine Anagnostou , Sabita Islam, Yvonne King , Loraine Foley, Laura Pasea, Simon Bond , Chris Palmer , John Deighton , Pamela Ewan, Andrew Clark Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial The Lancet, Early Online Publication, 30 January 2014

Clark A, Mangat J, King Y, Islam S, Anagnostou K, Foley L, Deighton J, Ewan P. Thermographic imaging during nasal peanut challenge may be useful in the diagnosis of peanut allergy. Allergy. 2012 Apr;67(4):574-6.

Clark A, Islam S, King Y, Deighton J, Szun S, Anagnostou K, Ewan P. A longitudinal study of resolution of allergy to well-cooked and uncooked egg. Clin Exp Allergy. 2011 May;41(5):706-12.

Anagnostou K, Clark A, King Y, Islam S, Deighton J, Ewan P. Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome. Clin Exp Allergy. 2011 Sep;41(9):1273-81.

Clark AT, Islam S, King Y, Deighton J, Anagnostou K, Ewan PW. Successful oral tolerance induction in severe peanut allergy. Allergy. 2009 Aug;64(8):1218-20.