Research
Inflammatory processes are crucial for host defence during infection, but excessive inflammation underpins many intractable human and animal diseases. Understanding how inflammation is initiated and regulated during infection is crucial for the development of vaccines and anti-inflammatory therapeutics. My work aims to understand how pathogens are sensed by the innate immune system and how these sensing pathways converge to stimulate inflammatory and cell death responses.
Publications
Webster SJ* and Goodall JC
New concepts in Chlamydia induced inflammasome responses
Microbes and Infection August 2018 (*corresponding author)
Webster SJ*, Brode S, Ellis L, Fitzmaurice T, Elder M, Gekara N, Toulomousis P, Bryant CE, Clare S, Chee R, Gaston JSH and Goodall, JC
Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection
PLOS Pathogens June 2017 (*joint corresponding author)
Webster SJ, Ellis L, O’Brien L, Tyrrell B, Fitzmaurice T, Elder M, Gaston JSH and Goodall JC.
IRE1α mediates PKR activation in response to Chlamydia trachomatis infection
Microbes Infect. 2016 Jul-Aug;18(7-8):472-83
Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte MKB and Dockrell DH.
Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.
Journal of Immunology; 2010; 185 (5): 2968-79
