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Si Ming Man

Research Interests

Supervisor: Dr Clare Bryant

My research investigates the role of inflammasome activation in the host defense against Salmonella enterica serovar Typhimurium (S. Typhimurium). The inflammasome is a multimeric protein platform that processes members of the IL-1 family, pro-IL-1β and pro-IL-18, into their mature forms. I am interested in investigating the activation and formation of the inflammasome to understand how this complex controls bacterial numbers in macrophages infected with S. Typhimurium.

Keywords

NLR ; macrophages ; epithelial cells ; inflammasome ; inflammatory mediators ; phagocytosis ; inflammation ; pattern recognition receptors ; nitric oxide ; dendritic cells ; Toll-like receptors ; Toll receptors

Topics

  • salmonellosis
  • inflammatory bowel disease
  • gastroenterology

Key Publications

Si Ming Man, Andrew Ekpenyong, Panagiotis Tourlomousis, Sarra Achouri, Eugenia Cammarota, Katherine Hughes, Alessandro Rizzo, Gilbert Ng, John A. Wright, Pietro Cicuta, Jochen R. Guck, and Clare E. Bryantvol. (2014) PNAS 111 no. 49 > 17588–17593, doi: 10.1073/pnas.1419925111

Actin polymerization as a key innate immune effector mechanism to control Salmonella infection
 a,2

Man, S.M. The clinical importance of emerging Campylobacter species. Nature Reviews Gastroenterology & Hepatology 2011. 8:669-685.

Man, S.M., Kaakoush, N.O., Mitchell, H.M. The role of bacteria and pattern-recognition receptors in Crohn’s disease. Nature Reviews Gastroenterology & Hepatology 2011. 8:152–168.

Man, S.M., Kaakoush, N.O., Leach, S.T., Day, A.S., Nahidi, L., Lu, H.K., Norman, J. Zhang, L., Mitchell, H.M. Host attachment, invasion and stimulation of pro-inflammatory cytokines by Campylobacter concisus and other non–C. jejuni Campylobacter species. The Journal of Infectious Diseases 2010 202:1855–1865.

Man, S.M., Zhang, L., Day, A.S., Leach, S.T., D.A. Lemberg., Mitchell, H.M.  Campylobacter concisus and other non-jejuni Campylobacter species in children with newly diagnosed Crohn’s Disease. Inflammatory Bowel Diseases 2010. 16:1008–1016.

Man, S.M., Kaakoush, N.O., Octavia, S., Mitchell, H.M. The Internal Transcribed Spacer region, a new tool for use in species differentiation and delineation of systematic relationships within the Campylobacter genus. Applied & Environmental Microbiology 2010. 76:3071–3081.

Kaakoush, N.O., Man, S.M., Lamb, S., Kovach, Z., Raftery, M., Wilkins, M.R., Mitchell, H.M.  The secretome of Campylobacter concisus. The Febs Journal 2010. 277:1606–1617.